The Effect of Ruangan Kangxian Prescription on TGF-β/Smad Pathway of Liver Fibrosis Rat

Objective To explore the structure and function of TGF-β/Smad pathway,and the relationship of it with liver fibrosis.Methods Use CCl4 and DMN induced liver fibrosis rat and model,and treat it by Ruangan Kangxian prescription,study the function and changes between model group and therapy group at relative pathway such as TGF-β1,Smad3,Smad7 and SARA.Results There are significant differences(P 0.05) between treated group and model group at Hyp ingredient and TGF-β1,Smad3,Smad7,SARA protein expression and TGF-β1,Smad3,Smad7 mRNA.The difference between treated group and control group groups were had no significant differences(P0.05).Conclusion Ruangan Kangxian prescription show reasonable effect on animal model,and can be used to further clinical study.