РОЛЬ НЕДИФФЕРЕНЦИРОВАННОЙ ДИСПЛАЗИИ СОЕДИНИТЕЛЬНОЙ ТКАНИ В РАЗВИТИИ ПАТОЛОГИИ ПОЗВОНОЧНИКА, СОЧЕТАЮЩЕЙСЯ С ЮВЕНИЛЬНОЙ ГЛАУКОМОЙ И МИОПИЕЙ

Objective. To study the influence of connective tissue dysplasia on the development of spine pathology, cardiovascular system, primary juvenile glaucoma, and myopia basing on a multimodal orthopaedic, pathomorphological, and ophthal-mological examination for optimization of diagnosis and treatment. Material and Methods. The multimodal examination of 50 patients with spine pathology combined with a primary juvenile glaucoma and acquired progressing myopia was performed. All patients passed through ophthalmologic, clinical-genealogical, orthopaedic, and cardiologic examination, with biochemical and pathomorphological investigation of surgical specimens. Spine pathology was assessed by a computer optical topography method. Results. Connective tissue dysplasia in patients with spine pathology is associated with ophthalmopathology and anomalies of cardiac valve and notochord. Structural metabolic changes of connective-tissue components of juxta-canalicular zone and sclera cause degenerative-dystrophic process accompanied by a dysfunction of eye drainage system synchronized with optic atrophy. Conclusion. Patients with spine pathology, with outer and innate phenotypic signs of connective tissue dysplasia should be referred to diagnostic ophthalmologic examination for detection and early treatment of acquired myopia and primary juvenile glaucoma.