Immunomodulatory effect of β‐carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer

Abstract Results from a number of studies suggest that β‐carotene‐containing foods prevent the initiation or progression of various cancers. One possible mechanism for this effect could be enhancement of the immune response. The aim of this study was to determine whether β‐carotene modulates ? lymphocyte subsets in patients affected with colonic polyps or cancerous lesions. Patients with previous adenomatous colonic polyps (n = 18) or colon cancers (n = 19) were randomized to receive placebo or β‐carotene (30 mg/day) for three months. Percentages of ? lymphocyte subsets were determined using flow cytometry in blood samples collected before randomization and at three months. ? lymphocyte subsets of 14 normal control subjects were also determined for comparison. Initially, there was no difference in total leukocyte counts, percentage of lymphocytes, and various subsets of lymphocytes among the three groups, although in cancer patients there was a lower percentage of CD4 and interleukin‐2 (IL‐2) receptor‐pos...