ENHANCING SOLUBILITY AND DISSOLUTION OF MEFENAMIC ACID BY FREEZE DRYING USING β - CYCLODEXTRIN

Mefenamic acid , an anti - inflammatory drug, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility a nd dissolution rate of Mefenamic acid by preparing microparticle by Freeze drying technique. Mefenamic acid microparticle containing different ratio of β - cyclodextrin were produced by Freeze drying using water and Isopropyl alcohol as solvent system to enhance solubility and dissolution rate. The prepared formulations containing different ratio of drug and polymer were evaluated for in vitro dissolution a nd solubility. The prepared formulations were characterized by scanning elec tron microscopy , differe ntial scanning calorimeter , X - ray diffraction and Fourier transform infrared spectroscopy. Dissolution profile of the Freeze dried microparticle was compare d with its physical mixture and pure sample. Freeze dried microparticle exhibited decreased crystallinity and the solubility and dissolution of the microparticle containing different ratio of drug and β cyclodextrin were significant improved compared with its physical mixture and pure sample of Mefenamic acid . Dissolut ion of microparticle containing 1:3 w/w ( FD 3 ) showed higher % release i.e. 9 8.6 % in 6 0 min compare to other formulation. Consequently, hence , from the above result it can be conclude that Freeze dried microparticle of Mefenamic acid is a useful technique to improve the solubility and dissolution of poorly water soluble drug like Mefenamic acid .