Role of Autophagy in Regulating Cyclin A2 Degradation: Live-Cell Imaging

2017 
Abstract Cyclin A2 is an essential regulator of the cell cycle. Its degradation by the ubiquitin-proteasome system (UPS) has been characterized for years. When studying cyclin A2 degradation, using notably high-resolution live-cell imaging, we recently showed that autophagy is an additional pathway for cyclin A2 degradation. After presenting data from the literature related to autophagy in general, and in particular during mitosis, we comment on our data regarding cyclin A2 degradation by autophagy and emphasize the interest of live-cell imaging in this context.
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