Observation of Fuzheng Shengbai decoction in preventing leukopenia during chemotherapy combined with radiotherapy in the same period

Objective To observe the effect of fuzheng shengbai decoction on incidence of leucopenia of patients with advanced lung cancer during chemotherapy combined with radiotherapy in the same period.Methods Sixty patients with lung cancer underwent chemotherapy combined with radiotherapy in the same period were randomly divided into treatment group and control group,patients in the treatment group were given radiotherapy and chemotherapy at the same time,fuzheng shengbai decoction 60 ml,each time 20 ml,three times daily.Patients in the control group were given from the first time of chemotherapy combined with radiotherapy,placebo 10ml +20 ml normal saline,three times a day.Two groups of patients were using 6 MeV accelerator or cobalt-60γ X-ray conventional fractionated external beam irradiation ( 1.8 - 2.0 Gy/time,5 times/week),generally use the first field on the chest and back,wearing two light DT 40 Gy,and to avoid spinal cord,together with the original tumor volume to total 60 - 70 Gy.Chemotherapy regimens are:cisplatin 25 mg/m2 ( dl - 3 ),VP-16 100 mg/m2 ( dl -3),every 21 days repeated × 6 cycles.Radiotherapy was given at the first cycle of chemotherapy.Results There were neutropenia grade comparison:leukopenia grade level Ⅱ,Ⅲ occured in 5,0 cases in treatment group,16,6 cases in the control group,there were significant differences between the two groups ( P ＜0.05).The incidence of neutropenia in treatment group was lower than that in the control group.Conclusions fuzheng shengbai decoction can prevent the occurrence of leukopenia. Key words: fuzheng shengbai decoction; Chemotherapy combined with radiotherapy; Leukopenia