Substituted indane derivatives and related heterocyclic compounds for the treatment of schizophrenia.

A dosage form comprising azithromycin ORAL AND AN EFFECTIVE AMOUNT alkalizing agent. Preferably, said oral dosage form comprising an amount EFFECTIVE AND AN AGENT ALCALIRIIZANTE azithromycin multiparticulate wherein said multiparticulate comprising azithromycin, a mixture of monobehenate glyceryl dibehenate, glyceryl tribehenate GLICERHO and a poloxamer. Typically, the oral dosage form includes any suitable oral administration AS AN ORAL SUSPENSION FOR DUST, a container or unit dose sachet, a tablet or capsule. EMAS DESCRIBED an oral suspension comprising azithromycin, AN AMOUNT OF AN EFFICIENT alkalizing agent and a vehicle. Preferably, the azithromycin in the form MUITIPARTICULADA IS IN SUCH multiparticulate comprising azithromycin, a mixture of monobehenate glyceryl glyceryl dibehenate and glyceryl tribehenate, and poloxamer. Lso DESCRIBES A PROCEDURE TO REDUCE SIDE EFFECTS Gastrointestinal associated with administration of azithromycin to a mammal, comprising administering contiguously form of azithromycin AND AMOUNT EFFECTIVELY A alkalizing agent to said mammal IN THE FREQUENCY Gastrointestinal Side Effects It is less than is experienced by administering an equal dose of azithromycin without said alkalizing agent. It is further disclosed a method for treating a bacterial or protozoal infection in a mammal in need thereof comprising the ministration contiguously to said mammal a single dose of an oral dosage form in which said dosage form ORAL comprising azithromycin AND AN EFFECTIVE AMOUNT alkalizing agent. ICIONALMENTE DESCRIBED azithromycin multiparticulates COMPRISING azithromycin, a surfactant; And a pharmaceutically acceptable carrier.