The More Complex Renin-Angiotensin System: New Insights Into An Old System

textabstractSince the first description of renin by Tigerstedt and Bergmann in 1898,1 the reninangiotensin system (RAS) has been extensively studied. In the last decades, many investigations have demonstrated the importance of the RAS for maintenance and regulation of many physiological processes. One of the most prominent functions of the RAS is the regulation of blood pressure and water homeostasis.