Scale-up of agitation fluidized bed granulation. II: Effects of scale, air flow velocity and agitator rotational speed on granule size, size distribution, density and shape
1995
Scale-up characteristics of agitation fluidized bed granulation using a pharmaceutical standard formulation was described. The effects of scale, air flow velocity and agitator rotational speed on granule properties such as granule mass median size, size distribution, apparent density and shape factor were investigated experimentally. Based on the results obtained, the effects of these parameters on granule growth and the mechanism of granule formation in different sized equipment were discussed
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