Synthesis and antiviral activity of azoles obtained from carbohydrates

Abstract Herein we describe the synthesis of 1,2,4-triazolyl-3-thione;1,3,4-oxadiazole, and imidazo[2,1- b ]thiazole derivatives from carbohydrates. The antiviral activity of these compounds was tested against Dengue and Junin virus (the etiological agent of Argentine hemorrhagic fever). The 3-( p -bromobenzoyl)-5-(1,2- O -isopropylidene-3- O -methyl-α- d- xylofuranos-5-ulos-5-yl)imidazo[2,1- b ]thiazole was able to inhibit the replication of both viruses in Vero cells at concentration significantly lower than the CC 50 .