Schistosomes of small mammals from the Lake Victoria Basin, Kenya: new species, familiar species, and implications for schistosomiasis control.

SUMMARY Recent schistosomiasis control efforts in sub-Saharan Africa have focused nearly exclusively on treatment of humans withpraziquantel.However,theextenttowhichwildmammalsactasreservoirsforSchistosomamansoniandthereforeassourcesof renewed transmission following control efforts is poorly understood. With the objective to study the role of smallmammals as reservoir hosts, 480 animals belonging to 9 rodent and 1 insectivore species were examined for infection withschistosomes in Kisumu, in the Lake Victoria Basin, Kenya. Animals were collected from 2 sites: near the lakeshore andfrom Nyabera Marsh draining into the lake. A total of 6.0% of the animals captured, including 5 murid rodent species and1 species of shrew (Crocidura olivieri) were infected with schistosomes. Four schistosome species were recovered andidentified using cox1 DNA barcoding: S. mansoni, S. bovis, S. rodhaini and S. kisumuensis, the latter of which was recentlydescribed from Nyabera Marsh. Schistosoma mansoni and S. rodhaini were found infecting the same host individual(Lophuromys flavopunctatus), suggesting that this host species could be responsible for the production of hybrid schisto-somes found in the area. Although the prevalence of S. mansoni infection in these reservoir populations was low (1.5%),given their potentially vast population size, their impact on transmission needs further study. Reservoir hosts couldperpetuate snail infections and favour renewed transmission to humans once control programmes have ceased.Key words: schistosomiasis control, rodents, insectivores, reservoir hosts, Africa, Kenya, Schistosoma kisumuensis,Schistosoma mansoni, Schistosoma bovis, Schistosoma rodhaini, control, barcoding.