Effects of Dehydration on Corneal Tissue Absorption of Topical Azithromycin in Rabbits
2005
Purpose: To assess the corneal tissue absorption of azithromycin in desiccated and normal eyes of rabbits. Methods: A total of 25 New Zealand Albino rabbits weighing 2–3 kg each were included. One eye of each rabbit was desiccated. The other eye was left as control. Azithromycin 1.5% topical eyedrops were instilled in both eyes. Five rabbits were sacrificed at each of the following time points: 30 min, 3 hr, 6 hr, and 12 hr. Corneal tissues specimens were subjected to high-performance liquid chromatography mass spectrometry. A paired t test was used to evaluate the statistical difference in corneal tissue absorptions of azithromycin at each time point. Results: The mean corneal tissue levels of azithromycin in dry eyes were 66.3 μ g/ml, 92.6 μ g/ml, 117.5 μ g/ml, and 179.9 μ g/ml, and the mean corneal tissue levels of azithromycin in normal eyes were 42.0 μ g/ml, 43.4 μ g/ml, 43.3 μ g/ml, and 80.0 μ g/ml at 30 min, 3 hr, 6 hr, and 12 hr respectively. Both groups showed increase in corneal tissue absorptio...
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