Perflubron (Perfluorooctylbromide) Instillation Combined with Mechanical Ventilation: An Alternative Treatment of Acute Respiratory Failure in Adult Animals

Experimental studies have shown that adequate gas exchange can be accomplished during liquid ventilation with oxygenated perfluorocarbons (PFC) in animals with respiratory failure in which conventional mechanical ventilation could be insufficient to support life [1,2]. Moreover, a number of studies have reported improvements in lung functions after liquid ventilation which has been attributed to the residual PFC in the lungs [3,4].