CONCENTRATIONS OF POLYFLUOROALKYL CHEMICALS DURING GESTATION AND SERUM LIPIDS AT AGE 7 IN GIRLS ENROLLED IN THE AVON LONGITUDINAL STUDY OF PARENTS AND CHILDREN

Background and aims: Polyfluoroalkyl chemicals (PFCs) are commercially synthesized chemicals used in consumer products. Exposure to PFCs is widespread and some PFCs may disrupt signaling processes involved in the control of lipid metabolism. We explored associations of maternal concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexane sulfonate (PFHxS) during gestation with serum lipid concentrations at age 7 in girls. Methods: Analyses were conducted on a sample of 227 singleton girls and their mothers participating in the Avon Longitudinal Study of Parents and Children. PFC concentrations were measured in serum samples obtained from the mothers at pregnancy. Cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides were measured in serum samples obtained from the girls at age 7. Linear regression models were used to estimate the average change in lipids levels for each 1-unit increase in the natural logarithm (Ln) of the PFCs af...