Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications
2020
This study represents
a successful approach toward employing polycaprolactone–polyamidoamine
(PCL–PAMAM) linear dendritic block copolymer (LDBC) nanoparticles
as small-molecule carriers in NIR imaging and photothermal therapy.
A feasible and robust synthetic strategy was used to synthesize a
library of amphiphilic LDBCs with well-controlled hydrophobic-to-hydrophilic
weight ratios. Systems with a hydrophobic weight ratio higher than
70% formed nanoparticles in aqueous media, which show hydrodynamic
diameters of 51.6 and 96.4 nm. These nanoparticles exhibited loading
efficiencies up to 21% for a hydrophobic molecule and 64% for a hydrophilic
molecule. Furthermore, successful cellular uptake was observed via
trafficking into endosomal and lysosomal compartments with an encapsulated
NIR theranostic agent (C3) without inducing cell death. A preliminary
photothermal assessment resulted in cell death after treating the
cells with encapsulated C3 and exposing them to NIR light. The results
of this work confirm the potential of these polymeric materials as
promising candidates in theranostic nanomedicine.
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