Study of Excess Fluoride Ingestion and Effect on Liver enzymes in Children Living in Jodhpur District of Rajasthan

The study was carried out in selected villages of Jodhpur district of Rajasthan. Study area was divided into four categories with different fluoride level in drinking water. Total 100 children aged 8–14 years were screened for dental fluorosis and biochemical analysis. 25 children were selected from each category. The dental fluorosis case was determined following dean's classification. Fluoride level in blood (serum) sample was estimated with the help of F ion specific electrode (Thermo Scientific Orion Star A329, USA), by Hall et al. method. The serum samples of children were investigated to assess liver function using Auto analyzer. The current study reveals that Fluoride content in blood serum significantly associate with serum SGOT, SGPT and ALP level. Serum level of Fluoride and ALP significantly higher in children living in high Fluoride content drinking water.