Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga+/- mice

Aims/hypothesis O-GlcNAcylationplays a roleasa metabolic sensor regulating cellular signalling, transcription and metabolism. Transcriptionfactors and signallingpathwaysrelated to metabolism are modulated by N-acetyl-glucosamine (OGlcNAc) modification. Aberrant regulation of OGlcNAcylation is closely linked to insulin resistance, type 2 diabetes and obesity. Current evidence shows that increased O-GlcNAcylation negatively regulates insulin signalling,