Fully automatic intelligent infusion method and device based on model predictive control for large doses of insulin

2011 
The invention provides an intelligent method based on model predictive control for automatic infusion of large doses of insulin, which is characterized in that: a continuous glucose monitoring system (CGMS) and an insulin pump are used as the basis of hardware; online detection of food is carried out based on a strong tracking filter; when the food is detected, large doses of insulin is transfused immediately, and the amount of insulin depends on historical food; whether the dosage is needed to be increased is judged every 30 minutes based on the model predictive control, and the dosage is designed; when the blood glucose concentration decreases, whether the basic amount of insulin is needed to be maintained is determined according to the predicted blood glucose value; and finally the blood glucose concentration is controlled to be within the safe range. Compared with the existing corresponding technology, the invention has the advantages of high degree of intelligence and fully automatic operation, and the blood glucose control effects can be improved significantly in case that self-management cannot be carried out by patients.
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