Experimental Study on the Functions of Making Diarrhea and Stopping Bleeding of Tongbian Capsule

Objective Observing the functions of making diarrhea and stopping bleeding of Tongbian capsule. Method Making the models of constipation on mice by stopping presenting water but providing food, while applying running pigment and taking black carbon powder as the instruction. Taking the time and quantity of black defecate as the index to observe the function of making diarrhea of the Tongbian capsule. Watching the function of propulsion, wriggling of the medicine on large intestine according to the propulsion rate of the ink in the large intestine of rat. We proved the stop bleeding function of Tongbian capsule by following ways:determine the bleeding and clotting time of mouse by cutting tail and using capillary, comparing the plasma prothrombin time of rabbit before and after taking the medicine, determine the penetration change of capillary by the light density value of the cleaning solution of abdominal cavity, etc. Result For the constipation mice, the Tongbian capsule can shorten defecate time of increasing quantity obviously (P0.01). And it has obvious functions of propulsion, wriggling on large intestine of rat (P0.01). Comparing with the blank group, the Tongbian capsule group and the positive comparison group can shorten bleeding and blood coagulation time of mice obviously (P0.01). There is no significance of bleeding time between the large dose group and the Anluoxue group (P0.05), neither are the middle dose group and the Vit K3 group (P0.05), but so are the large dose group and the Vit K3 group (P0.05). The plasma prothrombin time of rabbit was shortened after taking the medicine (P0.05). Comparing with the blank group, both Tongbian Capsule group and the Anluoxue group can restrain the penetration of capillary in abdominal cavity of mice (P0.01). Conclusion The Tongbian capsule has good effects of making diarrhea and stoppin bleeding.