ضایعات متعدد ژانت سل گرانولوما مرتبط با هیپر پاراتیروئیدیسم ثالثیه: گزارش مورد

Introduction: Excessive secretion of parathyroid hormone results in hyperparathyroidism which is classified into primary, secondary and tertiary categories. Tertiary hyperparathyroidism develops rarely in some patients with secondary hyperparathyroidism due to long-term and persistent renal disease and consequently autonomous hyperplasia or adenoma of one or more parathyroid glands. Classic triad signs of hyperparathyroidism, including renal stones, osseous changes and duodenal ulcers are also observed in this type. Sometimes giant cell granulomas of jaws are related to hyperparathyroidism. Case report: The patient was a 56-year-old female complaining of a prominent lesion in the left mandibular body. The medical history of the patient indicated chronic renal disease. Based on clinical, laboratory, radiographic and histopathological findings, a diagnosis of giant cell granuloma related to hyperparathyroidism was suggested. Conclusion: In secondary hyperparathyroidism that develops in renal patients or patients undergoing long-term dialysis, blood calcium levels are normal or below normal, but phosphorus and alkaline phosphatase levels increase. In tertiary hyperparathyroidism, similar to primary hyperparathyroidism, calcium and alkaline phosphatase levels increase but phosphorus levels decrease. In all types of hyperparathyroidism, osseous changes occur, the most significant of which is giant cell granuloma. Key words: Alkaline phosphatase, Giant cell granuloma, Hyperparathyroidism