Comparison of Management Strategies for the Neonate with Symptomatic Tetralogy of Fallot and Weight Less than 2.5 kg

Abstract Objective To compare management strategies for neonates Methods Consecutive neonates with sTOF weighing Results The cohort included 76 SR (IP: 53 surgical; 23 transcatheter) and 44 PR patients. The observed risk of overall mortality was similar between SR and PR groups (15.8 vs. 18.2%, p=0.735). The adjusted hazard of mortality remained similar between groups overall (HR 0.59 (95% CI 0.26-1.36), p=0.214), as well as during short-term ( 4 months: HR 1.32 (0.30-5.79), p=0.717) follow-up. Reintervention in the first 18 months was common in both groups (53.2 vs. 48.4%; HR 1.69 (95% CI 0.96-2.28), p=0.072). Adjusted procedural complications and neonatal morbidity burden were overall lower in the SR group. Cumulative secondary outcome burdens largely favored the PR group. Conclusions In this study comparing staged and primary repair treatment strategies for neonates with sTOF and weight