Иммуногенетика и прогрессирование хронических вирусных гепатитов

Aim of investigation. To estimate the role of polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC11A1 (D543N) in chronic viral hepatitis progression. Material and methods. Overall 121 patients with chronic viral hepatitis C and B. Results. Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the «Val/Val» IL4RA gene variant (II50Val) is associated with HBV-infection chronization. The allele «A» gene TNF-α (G-308A) is protective for chronic viral hepatitis and is associated with a low level of production by mononuclear cells of TNF-α and IL-12, high secretion of IL-4 and low degree of collagenopathy in the liver. Genotype «CT» of IL4 (C-590T) gene is an adverse marker for progression of chronic viral hepatitis B. There was significant correlation of polymorphic variants TNF (G-308A) and IL4 (C-590T) genes with production of the key interleukins, that determine type of immune response (Th-1, Th-2) and products of collagen metabolism that testifies genetic determination of system immune response and collagen formation processes in the liver at chronic viral hepatitis.