Synthesis, Antileukemic Evaluation and Peroxidating Ability of Heterosubstituted Anthracene-9,10-dione Analogues: 5,8-((Aminoalkyl) amino)naphtho(2,3-d)thiazole-4,9-diones and 5,8-((Aminoalkyl)amino) naphtho(2,3-c)(1,2,5)thiadiazole-4

Abstract The syntheses of a number of heterosubstituted ametantrone analogues, 5,8-bis[(aminoalkyl)amino]naphtho[2,3- d ]thiazole-4,9-diones and 5,8-bis[(aminoalkyl)amino]naphtho[2,3- c ] [1,2,5]thiadiazole-4,9-diones, have been performed. It was evidenced that this modification in the chromophore moiety has a negative effect on antileukemic activity. This modification also favors the affinity of the compounds toward NADH dehydrogenase and influences the redox potential.