Thoracic impedance measurements during orthostatic change test and during hemodialysis in hemodialyzed patients.

Measurements were performed before and after hemodialysis (HD) in the supine and upright positions (orthostatic change test) and during HD session every 30 minutes in recumbent position on 11 HD patients. Two hydration states were compared: hyperhydration and normal hydration. Each patient served as his own control. Blood pressure and total body bioimpedance were obtained simultaneously. Thoracic impedance values (Zo) obtained during HD were significantly greater in the normal hydration state. There was strong correlation between Zo gain and total ultrafiltration; however, Zo gain divided through total ultrafiltration (calculated for every 100 ml) was also higher in this state. The ratio Zo/R (where R is resistance of total body bioimpedance) was stable during HD but was significantly higher in the normal hydration state. Zo gain during the orthostatic change test was significantly higher after HD than before HD in both hydration states. The anticipated difference in Zo gains between both hydration states was not significant. After echocardiographic analysis of patients, we determined that cardiac dysfunction or valvular defects in four patients were likely responsible for opposite reaction on orthostatic change test. During our measurements, we observed the influence of Zo changes on episodes such as intradialytic hypotension or acute atrial fibrillation. Thoracic impedance is an intriguing method for controlling pathophysiology of fluid distribution, but it requires the accurate definition of a patient's hemodynamics and strong conditions during measurement. During our measurements, we observed the influence of such episodes as intradialytic hypotension or acute atrial fibrillation on Zo changes.