Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens

Abstract A new abietane, namely, 20-hydroxyferruginol ( 1 ), together with known ferruginol ( 2 ), 18-hydroxyferruginol ( 3 ), sugiol ( 4 ), and 6α-hydroxysugiol ( 5 ), were isolated from the cones of Sequoia sempervirens . Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI 50 2–5 μg/mL.