The relationship between tocilizumab and autoimmune diseases

Over-production of interleukin-6 (IL-6) plays an essential role in rheumatic autoimmune diseases such as rheumatoid arthritis (RA),juvenile idiopathic arthritis (JIA)and systemic lupus erythematosus (SLE).Tocilizumab,the first humanized anti-human IL-6 receptor antibody,can bind IL-6R by specific recognition and subsequently block the biological activity of IL-6.A large number of studies have demonstrated that tocilizumab was effective not only in improving clinical manifestation but also in preventing joint destruction of RA.In addition,A great successs has been made in the treatment of systemic and articular types of JIA,Castleman's disease,SLE,Crohu's disease,etc,by the application of tolicizubmab. Key words: Tolicizumab ;  Interleukin-6 ;  Rheumatoid arthritis ;  Juvenile idiopathic arthritis ;  Systemic lupus erythematosus ;