Amphiphilic Polymeric Nanoparticles Modified with a Protease-Resistant Peptide Shuttle for the Delivery of SN-38 in Diffuse Intrinsic Pontine Glioma

Alexandra Bukchin,Macarena Sánchez-Navarro,Adam Carrera,Claudia Resa-Pares,Helena Castillo-Ecija,Leire Balaguer-Lluna,Meritxell Teixidó,Nagore G. Olaciregui,Ernest Giralt,Angel M. Carcaboso,Alejandro Sosnik

Amphiphilic Polymeric Nanoparticles Modified with a Protease-Resistant Peptide Shuttle for the Delivery of SN-38 in Diffuse Intrinsic Pontine Glioma

2021

Alexandra Bukchin
Macarena Sánchez-Navarro
Adam Carrera
Claudia Resa-Pares
Helena Castillo-Ecija
Leire Balaguer-Lluna
Meritxell Teixidó
Nagore G. Olaciregui
Ernest Giralt
Angel M. Carcaboso
Alejandro Sosnik

Diffuse intrinsic pontine glioma (DIPG) is a chemo-resistant, incurable pediatric tumor of the central nervous system (CNS). The blood–brain barrier (BBB) remains intact in the course of the diseas...

Keywords:

SN-38
polymeric nanoparticles
protease resistant
Amphiphile
Peptide
Cancer research
Pediatric Tumor
Central nervous system
Chemistry

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