Potential Margin Distortion in Breast Tissue by Specimen Mammography

Hypothesis There is a potential for margin distortion associated with the use of a compression plate in specimen mammography (SM) devices. Design Prospective observational study. Setting Two tertiary care teaching hospitals. Patients Breast biopsy tissue dimensions were recorded in 15 patients undergoing 18 operations before and after SM (group 1). After review of these data, we supervised the positioning of tissue for SM and obtained measurements for 12 breast biopsy specimens from 12 additional patients before and after SM (group 2). Main Outcome Measures Breast biopsy specimen dimensions recorded before and after SM, including length, width, and depth (the specimen depth along the axis of compression); data on age, menopausal status, hormone therapy, and the presence or absence of calcifications or tumor; and a national telephone survey on technique and understanding of SM at 21 institutions. Results The specimen depth in group 1 was markedly decreased ( P Conclusions This study demonstrates the potential for specimen margin distortion with compression SM. Undue specimen compression is common in routine SM. Surgeon oversight in the method of securing the specimen within the SM container will minimize or avoid the potential for margin distortion.