Injury apoptosis effects of Endoplasmic reticulum stress on the pancreatic β-cell
2010
As one of the most sensitive cells of endoplasmic reticulum stress,pancreatic βcells have an abundance of endoplasmic reticulum .It is the adaptive response of pancreatic β cells under Endoplasmic reticulum stress conditions.Internal and external factors in the environment such as oxidative damage,lipid toxicity and the effect of cytokines in the endoplasmic reticulum could breake the steady-state,resulting in barriers to folding or misfolding of protein,thereby to trigger endoplasmic reticulum stress.Serious and lasting stress will lead to β cell apoptosis,involved in a variety of metabohc diseases as well as a variety of diseases.This article gives a review on the injury effects of multi-factor induced endoplasmic reticulum stress on the pancreatic β-cell
Key words:
Endoplasmic reticulum stress; Pancreatic β-cell; Cell apoptosis
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI