Cervical interleukin-6 as a predictive test for preterm delivery in symptomatic women: preliminary results

Abstract Objective The aim of this study is to assess the efficacy of cervical interleukin-6 (IL-6) compared with cervical length and its association in the prediction of preterm delivery in symptomatic women. Study design Observational prospective study was performed at Hospital Universitario La Fe, Valencia (Spain). Sample: 100 women between 24 and 34 weeks gestational age, with threatened preterm delivery and intact membranes during the period 2006–2008. Methods Transvaginal scan to assess cervical length was performed and cervical swab for IL-6 detection was taken. Statistical analysis included Chi-square test, receiver operating characteristic (ROC) curve analysis, COX regression, logistic regression, and Kaplan–Meier survival analysis. Results The prevalence of preterm delivery at 210 pg/ml. No differences were observed between the area under the curve (AUC) of IL-6 and cervical length for the prediction of preterm delivery. The association of IL-6 (>210 pg/ml) and cervical length ( Conclusions Cervical IL-6 can predict preterm delivery similarly to cervical length; when combined, it adds prognostic information to that provided by sonographic measurement of the cervical length.