P-glycoprotein expression, tumor differentiation, chemosensitivity of tumor-cells in-vitro and clinical outcome in patients with renal-cell carcinoma.

: There was no association between expression of P-170 glycoprotein on cells derived from 14 renal carcinomas and the in vitro sensitivity of the cells to doxorubicin or its potentiation by verapamil. Furthermore expression of P-170 on the cells of individual tumours was unrelated to nuclear differentiation or patient prognosis. These observations may in part resolve the dilemma posed by the reported association in some tumour types between expression of P-170 and the metastatic phenotype together with the previously observed relation in renal carcinoma between P-170 expression, good tumour differentiation and therefore a favourable prognosis.