Cardiovascular Involvement in Primary Sjögren's Syndrome

Abstract Sjogren syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands and causes dryness of the main mucosal surfaces. When symptoms appear in a previously healthy person, the disease is classified as primary SjS. However, the clinical spectrum of SjS extends from dryness to systemic involvement (extraglandular manifestations) and includes a large number of organ-specific manifestations. Cardiovascular involvement is one of the extraglandular involvements less frequently studied in primary SjS, although a growing interest on investigating cardiovascular features in SjS patients has emerged from studies reported in the last 10 years.