A process for the preparation of sorbicillacton
2004
A process for the preparation of sorbicillacton or derivatives thereof, comprising the steps of: a) culturing a fungus of the genus Penicillium at 20-25 ° C in a suitable culture medium at a salt concentration of 2-5% by the formation of a compact Oberflachenmycels, b) raising the temperature to 28-35 ° C and further incubating for 5-10 days c) separating the culture fluid from the mycelium, and d) extracting Sorbicillacton A and derivatives thereof from the culture medium, and optionally, e) sub-layers of the mycelium with fresh medium with a reduced salt concentration of 0.5-1.5% and incubating at 28-35 ° C for 3-8 days, f) repeating step c) and d), and optionally, g) repeating steps e) to f), and h) extracting sorbicillactone A and derivatives thereof from the culture medium and / or the mycelia.
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