Pharmacokinetic properties of YM17E, an inhibitor of acyl coenzyme A : cholesterol acyl transferase, and serum cholesterol levels in healthy volunteers

We conducted a single and repeat oral dose study of YM17E, a novel inhibitor of acyl coenzyme A (CoA): cholesterol acyltransferase, in healthy male volunteers to evaluate the pharmacokinetic profile, tolerability and effect of the drug on serum cholesterol.