Субпопуляционная структура лимфоцитов при экспериментальной инфекции у мышей, вызванной вариантами одного штамма вируса клещевого энцефалита

Aim. To study the immunophenotypical peculiarities of mice lymphocytes in experimental infection caused by clones 57 and 58, as the variants of one Tick-borne encephalitis virus (TBEV) strain. Materials and methods. The influence of variants 57 and 58, extracted from the population of one TBEV strain, on immunophenotypical peculiarities of infected mice lymphocytes was studied. Results. In our study, variants 57 and 58 were close by their effect on the structure of lymphocyte subpopulations. The viruses did not influence T lymphocyte number, but in this or that extent, they caused decrease in the number of NKT ( p immune response, characterized by fall in the number of T lymphocyte, T helper, NK cell pools and rise in B lymphocyte level. Conclusions. Thus, the ability of TBEV variants, as the components of one viral population, to modulate effector functions of hereditary and adaptive immunity at early stages of infectious process was demonstrated.