Quantitative OCTA parameter variations after treatment of macular neovascularization secondary to age-related macular degeneration

Purpose Macular neovascularization (MNV) secondary to age-related macular degeneration (AMD) can be characterized by quantitative optical coherence tomography angiography (OCTA). The aim of the study was to assess the evolution of quantitative OCTA parameters after one-year of anti-VEGF injections. Methods Naive AMD-related MNV eyes were prospectively recruited to analyze OCT and OCTA parameters, including MNV vessel tortuosity (VT) and reflectivity, at baseline and at the end of the follow-up. MNV eyes were categorized by a MNV VT cutoff and quantitative parameter variations were documented after one-year of treatment. We divided MNV eyes into Group 1 (MNV VT 8.40). Results 30 naive AMD-related MNV eyes (30 patients) were included. Our cohort included 18 type 1 MNV and 12 type 2 MNV lesions. Baseline central macular thickness (411±85µm) improved to 323±54µm at 1-year (p Conclusions MNV VT provides information on the blood flow and identifies two subgroups with different final anatomical and visual outcomes, regardless of the treatment effect.