Rapid synthesis and quality control of 68Ga-labeled chelates for clinical use

Abstract Rapid synthesis of radiopharmaceuticals labeled with 68 Ga obtained from a 68Ge68Ga generator is described. Approximately 70% of the available 68 Ga activity was obtained in 4 mL 1 N HCl and evaporated to dryness in 5 min in a Rotovap system. Activity was reconstituted in 0.01 N HCl and 0.5 M NaAc, MPO added and pH adjusted to 6.7–7.0 with NaOH. Previously prepared human platelets were labeled with 68 Ga and reinjected within 1 h of eluting the generator.