The effect of Chinese Rhubarb by nasojejunal tube and nasogastric tube in assisting the treatment of severe acute pancreatitis: a Meta analysis

Objective To assess the effect of Chinese Rhubarb in assisting the treatment of severe acute pancreatitis (SAP) by nasojejunal tube (NJ) and nasogastric tube (NG). Methods Cochrane Library, PubMed, Embase, Science Citation Index Expanded-SCIE, EBSCO-CINAHL Complete, SinoMed, VIP network and Wan Fang net were retrieved systematically and randomized controlled trails (RCT) that involved in Chinese rhubarb assisting the treatment of SAP by NJ and NG were searched. According to eligibility and extraction standards, 2 researchers independently selected relevant literature and extracted the relevant data. The quality of literature was evaluated using criteria published by Australian Evidence-Based Health Care Center (2008). RevMan5.3 software was employed for Meta analysis. Results Eleven RCTs were enrolled and the quality of all the 11 papers was B grade. Compared with NG, NJ had lower score of APACHE-Ⅱ, shorter time of decreased CRP, amylase activity, IL-6 and IL-1, and shorter recovery time of bowel function and abdominal pain, and the differences were statistically significant (P<0.01). However, there were no significant differences between two groups on complication rate, mortality, the rate of bowel function failure, the rate of surgical operation and recovery rate. Conclusions Chinese Rhubarb by NJ irrigation in assisting the treatment of SAP can rapidly alleviate abdominal pain, promote bowel function recovery and reduce inflammatory reaction, which had better efficacy than NG. Key words: Pancreatitis, acute necrotizing; Rheum; Nasojejunal tube; Nasogastric tube; Meta-analysis