The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders.

Abstract The suppressor of cytokine signalling-1 (SOCS-1) is a negative regulator of signal transduction mediated by cytoplasmic tyrosine kinases such as the Janus kinases (JAKs). We investigated SOCS-1 expression in bone marrow cells from Philadelphia chromosome negative chronic myeloproliferative disorders (Ph − CMPD) and normal haematopoiesis ( n  = 121), and additionally in peripheral blood samples ( n  = 18). Except for chronic idiopathic myelofibrosis harbouring wild-type JAK2, other Ph − CMPD expressed significantly higher SOCS-1 levels of up to 14-fold compared to the control group ( p − CMPD subtypes independent of an underlying JAK2 (V617F) mutation.