Determination and analysis of flutamide solubility in different solvent systems at different temperatures (T = 278.15–328.15 K)

Abstract In this research, the solubility properties of flutamide were studied by static equilibrium method under atmospheric pressure in twelve pure solvents (acetone, methanol, tetrahydrofuran, ethyl alcohol, ethyl acetate, isopropanol, n-propanol, n-butylalcohol, isobutanol, acetonitrile, methyl acetate, 1,4-dioxane) and three mixed solvents (acetone + isopropanol, ethyl acetate + isopropanol, tetrahydrofuran + isopropanol) with the experiment temperature was set from 278.15 K to 323.15 K. The purpose of this article was studying the solubility properties of flutamide in diverse solvent systems, which can provide references for selecting good solvent and antisolvent in process of crystallize. Modified Apelblat and λh model fit the solubility data which were get from pure solvents. Their RADmax were 1.73% and 2.05%, respectively, their RMSDmax were 0.29% and 0.44%, respectively. At the same time, CNIBS/R–K and Jouyban–Acree model match the solubility data which were get from binary solvent mixtures. Their RADmax were 0.47% and 4.21%, respectively, their RMSDmax were 0.22% and 0.32%, respectively.