Fetal İntrahepatik Kalsifikasyon ve Dengeli Resiprokal Translokasyon Taşiyiciliği Fetal Intrahepatic Calcification and Balanced Resiprocal Translocation Carrier

Fetal hepatic calcifications are relatively common with an estimated incidence of 1:1037 to 1:1750. At least 20% of these are associated with karyotype abnormalities,trisomy 13 being the most common. Isolated cases are reported to generally have good outcomes. The calcifications can either be parenchymal or on the hepatic surface. Routine midtrimester detailed ultrasound scan of a 28-year-old gravida 1, para 0 pregnant woman at 21+ 2/7 weeks of gestation revealed a prominent hyperechogenic foci on the right side of fetal abdomen concordant with fetal hepatic surface calcification. Detailed fetal ultrasonography including fetal echocardiography and 3-dimensional neurosonography showed no additional findings. Karyotype by amniocentesis revealed a balanced translocation between chromosomes 7 and 11 that was found to be paternally inherited. Maternal serology for toxoplasmosis, cytomegalovirus, rubella, parvovirus B 19 and syphilis were negative. There maining routine pregnancy follow-up was uneventful. A healthy fetus at term was delivered and is well with no medical problems at 12 months of age. Isolated fetal hepaticsurface calcifications seem to have a good prognosis. Whether fetuses carrying certain balanced reciprocal chromosome translocations are at risk of hepatic calcification requires further study.