Клинический случай развития синдрома Лайелла у больной, страдающей псориазом

The medicinal polypragmasy is potentially life-threatening for a patient. As a result of the simultaneous (quite often unreasonable) prescription of many medicines the conditions for interaction not only initial substances, but also their metabolites are created. As a result high-allergenic complexes and conjugates may arise. One of the most severe allergic reactions (after anaphylactic shock) is Lyell’s syndrome. The clinical observation of toxic epidermal necrolysis in patients suffering from psoriasis has been presented. Lyell’s syndrome arose against a polypragmasy (hofitol, tsetrin, berroko plus paracetamol, chondroitin). At the time of occurrence and treatment of toxic epidermal necrolysis clinical manifestations of psoriasis were in a remission stage. In 2 weeks after successful treatment of toxic epidermal necrolysis, the patient appeared exacerbation of psoriasis. Lyell’s syndrome was a trigger factor.