Troponin Mutations in Cardiomyopathies

Cardiomyopathies are a group of cardiac disorders characterized by structural and functional abnormalities of the myocardium of unexplained aetiology. By convention idiopathic cardiomyopathies are divided into 4 different diagnostic entities: Hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM) and arrythmogenic right ventricle cardiomyopathy (ARVC) (Figure 18.1).1 Recent investigations have revealed that the conditions in many cases are hereditary.2, 3, 4