NF-κB and the onset and progression of hepatocellular carcinoma

Hepatocellular carcinoma is one of the malignant tumors with highest mortality. Nuclear factor κB (NF-κB) as the mediator of many pathways, such as metabolic pathway, angiogenesis and adherence factor, is implicated in the onset and progression of hepatocellular carcinoma. Through the literature retrieval, the activity of NF-κB and its implication in the onset, progression, invasion and metastasis have been reviewed in the article. Key words: NF-kappa B; Liver neoplasms; Review