Chlorophenol graphene-based molecularly imprinted solid-phase extraction column and preparation method and application thereof

The invention relates to a chlorophenol graphene-based molecularly imprinted solid-phase extraction column, which comprises an empty column, a sieve plate and a filling material. The filling material is formed by mixing chlorophenol graphene molecularly imprinted nanoparticles and a conventional solid-phase extraction packing at the mass ratio of 1: 1-10. According to the chlorophenol graphene molecularly imprinted nanoparticles, a magnetic Fe3O4 high-molecular material is supported on the surface of graphene as a function unit, and a target chlorophenol compound to be adsorbed is used as template molecule. Meanwhile, the invention also relates to a preparation method and an application of the chlorophenol graphene-based molecularly imprinted solid-phase extraction column. The chlorophenol graphene-based molecularly imprinted solid-phase extraction column has large specific surface area, many adsorption sites, strong specific selectivity and good enrichment effect, can be used in enrichment of residual trace amount of chlorophenol compounds in an environmental water sample, and can achieve high enrichment factor and can remarkably reduce matrix effects. Meanwhile, the preparation method of the molecularly imprinted solid-phase extraction column is simple, technological conditions are stable, and production cost is low.