Relationship between insulin administration and substrates oxidation during continuous aerobic exercise in adolescents with type 1 diabetes mellitus

Materials and methods Six patients with type 1 diabetes mellitus were evaluated: 6 pubertal, BMI Z-score 0.56±0.48; chronological age 13.7±2.6y; duration of disease 6.5±4.26y; mean HbA1c 9.13±1.7%. Patients took breakfast and insulin at the clinic (mean basal insulin 0.47±0.07U/kg/d and fast insulin 0.33±0.12U/kg/d). Continuous ergometric test at moderated intensity (60% VO2max) was performed for 30 min, one and two h after insulin (T1 and T2). Intensity was controlled through oxidation and heart rate measured at 10 and 30 min of exercise with K4b2 gas analyzer. Blood glucose levels were measured at the beginning, 10 and 30 min.