Nitrous oxide inhalation sedation in dentistry: an overview of its applications and safety profile

: Nitrous oxide in oxygen (N2O/O2) inhalation sedation is used less commonly by Singapore dentists than their counterparts in the United Kingdom and the United States. Using this technique, trained dentists often perform the dual roles of a sedationist and an operating dentist. This paper describes the mechanism of action of N2O and highlights the modern gas delivery system commonly used in dentistry. The built-in safety features of this unique system helps to ensure that patient-specific therapeutic dosages are effectively and safely administered by dentists. Existing evidence for adverse events and the safety profile of the N2O/O2 inhalation sedation is discussed. Finally, recommendations of equipment, training and techniques for safe N2O/O2 inhalation sedation are provided.