Cardiovascular actions of prostaglandin F2α infusion in man

Abstract The effect of PGF 2α on the cardiovascular system in six normal volunteers was studied by intravenous infusion of 0.01–2.0 μg/kg/min. This prostaglandin had no effect on the systolic and diastolic blood pressures, heart rate, ECG or the respiration rate. Similarly rapid single intravenous injections of 1–40 μg of PGF 2α did not alter any of these parameters. One volunteer was also infused with 0.2 μg/kg/min of prostaglandin E 1 for 30 min. This produced an increase in heart rate and a fall in systolic and diastolic pressures.