Sperm exposure during menses is a risk factor for developing antisperm antibody (ASA) in female

Purpose Intercourse during menses is a sexual behavior practiced by 3–30 % of sexually active women. Defense responses of mucosal immunity in the female genital tract regulated by sex hormones would be impaired during menses. The present study seeks to clarify whether unprotected sexual activity during menses will increase the risk for antisperm antibody (ASA) production in female.