INNOVATIVE PRECISION MEDICINE APPROACHES FOR THROMBO-INFLAMMATORY DRIVEN CARDIOVASCULAR DISEASES

Cardiovascular disease remains the leading cause of death worldwide, mainly driven by higher prevalence of risk factors such as diabetes and obesity. This thesis explores novel strategies to address the underlying thrombotic and inflammatory pathways that drive atherosclerosis, vulnerable plaque and aneurysm. This work encompasses a multitude of methods ranging from biomarker biology, biotechnology of antibody design and production, conjugation chemistry and various imaging modalities. It focuses on the development of a precision medicine approach via targeted theranostic tools providing visualisation of the disease and simultaneous direct and site-specific drug delivery and the ability to monitor therapeutic effects over time.